Can Azelaic Acid Be Used with Retin-A?
When it comes to skincare, using powerful ingredients can feel like mixing potions in a bubbling cauldron. Some of the most potent options—like Retin-A and azelaic acid—seem straight out of a skincare spell book.
But here’s the real magic question: Can azelaic acid be used with Retin-A?
If you’ve been wondering how to use these two powerhouse ingredients safely and effectively, this post will guide you through everything you need to know.
What Are the Benefits of Retin-A?
Retin-A, also known as tretinoin, is a prescription-strength derivative of vitamin A. It’s widely considered one of the most effective skincare ingredients available today.
Here are the top benefits of adding Retin-A to your skincare routine:
Regulates oil production: Perfect for acne-prone or oily skin types.
Fades dark spots and hyperpigmentation: Gradually lightens discoloration and evens out skin tone.
Boosts skin cell turnover: Speeds up your skin’s natural exfoliation cycle to reveal brighter skin.
Targets signs of aging: Smooths fine lines, softens wrinkles, and improves skin elasticity.
Despite its impressive benefits, Retin-A is also known for potential side effects like dryness, peeling, and irritation. This is why it’s important to use it properly.
Retin-A also breaks down in sunlight, so it should always be applied at night. Make sure to follow up with SPF 30 or higher during the day to protect your skin.
What Are the Benefits of Azelaic Acid?
Azelaic acid is a naturally occurring acid found in grains like wheat, rye, and barley. In skincare, a synthetic version is used for purity and consistency.
Although it’s often overlooked, azelaic acid offers a wide range of skin benefits:
Anti-inflammatory properties: Great for calming redness, rosacea, and irritation.
Anti-bacterial action: Helps reduce acne-causing bacteria and unclog pores.
Gentle exfoliation: Smooths rough skin and clears away dead skin cells.
Brightens skin tone: Reduces hyperpigmentation, post-acne marks, and uneven texture.
It’s ideal for those with sensitive or reactive skin, as it’s generally less irritating than other actives like glycolic acid or retinol.
While azelaic acid may take longer to show visible results, consistent use can significantly improve your complexion without harsh side effects.
Can I Use Azelaic Acid and Retin-A Together?
Yes, you can use azelaic acid with Retin-A—but you need to apply them correctly to avoid irritation and achieve the best results.
These two actives are both strong and effective, which means they can irritate the skin if not introduced properly or layered incorrectly.
There are three main ways to combine them safely in your skincare routine:
1. Alternate Their Use on Different Nights
One of the safest approaches is to alternate between azelaic acid and Retin-A on different evenings. For example:
Monday, Wednesday, Friday: Use Retin-A
Tuesday, Thursday, Saturday: Use azelaic acid
Sunday: Give your skin a break or apply only hydrating products
This approach prevents over-exfoliation and gives your skin time to recover between actives.
2. Use Azelaic Acid in the Morning and Retin-A at Night
Another effective method is to split them between day and night. Use azelaic acid in your morning routine and apply Retin-A in the evening.
Azelaic acid is stable in sunlight and does not cause photosensitivity like other acids. Just remember to still wear sunscreen during the day.
This way, both ingredients can work independently without overwhelming your skin.
3. Use Them in the Same Routine with Proper Spacing
If your skin is well-adjusted to both ingredients, you may be able to apply them during the same routine. But spacing is key.
Apply one active, wait 20–30 minutes, then apply the second. This gives your skin time to rebalance its pH and prevents product conflict.
Make sure to follow with a gentle moisturizer to protect your barrier and lock in hydration.
Which Goes First: Azelaic Acid or Retin-A?
The order depends on the texture of the products you’re using. Follow the basic skincare rule: apply products from thinnest to thickest.
If your azelaic acid product is a lightweight toner or serum and your Retin-A is a cream, apply azelaic acid first. Then follow with Retin-A.
A sample routine might look like this:
Cleanse
Apply azelaic acid serum or toner
Wait 20–30 minutes
Apply Retin-A
Finish with a moisturizer
If both products are serums or creams with similar textures, choose based on skin needs or alternate nights to reduce potential irritation.
Can I Combine These With Other Ingredients?
Yes—but be cautious. Here are a few ingredients that pair well with both azelaic acid and Retin-A:
Niacinamide: Helps calm the skin and lock in hydration. Great for reducing redness and strengthening the barrier.
Hyaluronic acid: Provides deep hydration without irritation and supports skin healing.
Ceramides: Replenish and protect the skin barrier, especially helpful when using strong actives.
Avoid pairing strong exfoliants like glycolic acid or salicylic acid in the same routine as Retin-A and azelaic acid unless guided by a dermatologist.
Is Azelaic Acid Better Than Retin-A?
That depends on your skin’s needs. Here’s a quick breakdown to help you decide:
Choose Azelaic Acid If:
You have sensitive skin that reacts easily to strong actives
You’re treating rosacea, redness, or mild acne
You want a gentler exfoliant that improves skin tone gradually
Choose Retin-A If:
Your primary concerns are wrinkles, fine lines, or loss of elasticity
You’re targeting moderate to severe acne
You want a faster result with more intensive cell turnover
Some people even find it beneficial to start with azelaic acid before slowly introducing Retin-A to help their skin adjust.
Who Should Avoid Using Both Together?
If you have extremely dry, flaky, or easily irritated skin, using both at the same time might be too much for your barrier.
Start slow. Always do a patch test when introducing a new active. Use a small amount on the jawline or neck and monitor for 24 hours.
And always consult your dermatologist before combining strong prescription products like Retin-A with other actives.
Tips for Using Retin-A and Azelaic Acid Together
Hydrate deeply: Use products with hyaluronic acid, glycerin, or ceramides to keep the skin barrier healthy.
Introduce slowly: Start with one ingredient and wait 2–3 weeks before adding the other.
Protect daily: Wear SPF 30 or higher every day, especially if using Retin-A.
Be patient: Results take time. Give your skin 6–12 weeks to adjust and show visible improvements.
Simplify your routine: Avoid overloading your routine with too many actives at once.
Conclusion: Can You Use Azelaic Acid with Retin-A?
Yes—you can use azelaic acid with Retin-A, and they can be a powerful duo when used correctly. The key is to introduce them gradually and listen to your skin.
Alternate their use, space out their application, and always prioritize hydration and sun protection. Used wisely, this combination can help improve acne, pigmentation, and signs of aging.
If you’re still unsure about how to add these ingredients to your routine, reach out to a skincare professional or dermatologist for personalized advice.
For more skincare tips, expert routines, and product recommendations, follow us on Instagram @BeautyInsiders. Or browse our blog for in-depth posts on azelaic acid, Retin-A, and everything in between.